1 1 Rift Valley fever virus MP - 12 vaccine is fully attenuated by a combination of 2 partial attenuations in the S - , M - and L - segments 3 4
نویسندگان
چکیده
4 Tetsuro Ikegami,1,2,3* Terence E. Hill,1 Jennifer K. Smith,1,4 Lihong Zhang,1,4 Terry L. 5 Juelich,1,4 Bin Gong, 1,3,4 Olga A.L. Slack, 1† Hoai J. Ly, 1 Nandadeva Lokugamage, 1 6 Alexander N. Freiberg,1,2,3,4 7 8 Department of Pathology, The Sealy Center for Vaccine Development, The Center for 9 Biodefense and Emerging Infectious Diseases, Galveston National Laboratory, The 10 University of Texas Medical Branch at Galveston, 301 University Blvd. Galveston, Texas 11 77555 USA 12 13 Running title: RVFV MP-12 attenuation 14 15 *Address correspondence to Tetsuro Ikegami, Department of Pathology, University of 16 Texas Medical Branch, MMNP3.206D, 301 University Blvd. Galveston, TX 77555-0436. 17 Phone: (409)-772-2563. Fax: (409)-747-1763. E-mail: [email protected]. 18 19 Present address : Olga A.L. Slack, GlaxoSmithKline, 45 Sidney St. Cambridge, MA 20 02139 21 22
منابع مشابه
Rift Valley Fever Virus MP-12 Vaccine Is Fully Attenuated by a Combination of Partial Attenuations in the S, M, and L Segments.
UNLABELLED Rift Valley fever (RVF) is a mosquito-borne zoonotic disease endemic to Africa and characterized by a high rate of abortion in ruminants and hemorrhagic fever, encephalitis, or blindness in humans. RVF is caused by Rift Valley fever virus (RVFV; family Bunyaviridae, genus Phlebovirus), which has a tripartite negative-stranded RNA genome (consisting of the S, M, and L segments). Furth...
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Rift Valley fever virus (RVFV; genus Phlebovirus, family Bunyaviridae) is a mosquito-borne zoonotic pathogen which can cause hemorrhagic fever, neurological disorders or blindness in humans, and a high rate of abortion in ruminants. MP-12 strain, a live-attenuated candidate vaccine, is attenuated in the M- and L-segments, but the S-segment retains the virulent phenotype. MP-12 was manufactured ...
متن کاملRisk analysis of inter-species reassortment through a Rift Valley fever phlebovirus MP-12 vaccine strain
Rift Valley fever (RVF) is a mosquito-borne zoonotic disease endemic to Africa and the Arabian Peninsula. The causative agent, Rift Valley fever phlebovirus (RVFV), belongs to the genus Phlebovirus in the family Phenuiviridae and causes high rates of abortions in ruminants, and hemorrhagic fever, encephalitis, or blindness in humans. Viral maintenance by mosquito vectors has led to sporadic RVF...
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متن کاملSafety and immunogenicity of a mutagenized, live attenuated Rift Valley fever vaccine, MP-12, in a Phase 1 dose escalation and route comparison study in humans.
Rift Valley fever (RVF) poses a risk as a potential agent in bioterrorism or agroterrorism. A live attenuated RVF vaccine (RVF MP-12) has been shown to be safe and protective in animals and showed promise in two initial clinical trials. In the present study, healthy adult human volunteers (N=56) received a single injection of (a) RVF MP-12, administered subcutaneously (SQ) at a concentration of...
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